| 产品名称 | VU 0029767 |
| 产品货号 | Axon 1988 CAS [326001-01-8] MF C21H21N3O3MW 363.41 Purity: 98% Soluble in DMSO Description Positive allosteric modulator of M1. VU 0029767 potentiates the agonistic effect of ACh for M1 (Ki value shifted by VU0029767 (3, 10 and 30 M) and shifted the ACh competition curve by 1.7 0.8-, 4.9 2.0-, and 8.8 1.9-fold, respectively, compared to control (DMSO; Ki value 8.7 µM). VU0029767 potentiates ACh-mediated intracellular calcium mobilization, but not phospholipase D activation. References Certificates Categories Extra info J.E. Marlo et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol. 2009 Mar;75(3):577-88. P.J. Conn et al. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci. 2009 Mar;30(3):148-55. Certificate of Analysis Material Safety Data Sheet CNS CHRM1 A18 PAM of mAChR M1 that potentiates the agonistic effect of Ach Chemical name (E)-2-(4-ethoxyphenylamino)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide Parent CAS No. [326001-01-8] Order Size Unit Price Stock 10 mg €120.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
VU 0029767Axon 1988 CAS [326001-01-8] MF C21H21N3O3
Description
Positive allosteric modulator of M1. VU 0029767 potentiates the agonistic effect of ACh for M1 (Ki value shifted by VU0029767 (3, 10 and 30 M) and shifted the ACh competition curve by 1.7 0.8-, 4.9 2.0-, and 8.8 1.9-fold, respectively, compared to control (DMSO; Ki value 8.7 µM). VU0029767 potentiates ACh-mediated intracellular calcium mobilization, but not phospholipase D activation.
PAM of mAChR M1 that potentiates the agonistic effect of Ach
Chemical name(E)-2-(4-ethoxyphenylamino)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide Parent CAS No.[326001-01-8] |
| 产品资料 |
