产品名称

XL 388

产品货号

Axon 2951 CAS [1251156-08-7] MF C23H22FN3O4SMW 455.50 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

XL 388

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2951

CAS [1251156-08-7]

MF C23H22FN3O4S
MW 455.50

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Recently added

XL 388

Description

Highly potent, selective, ATP-competitive, and orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with an IC50 value of 9.9 nM. Moreover, XL 388 is an mTORC1/2 dual inhibitor which displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. XL 388 showed anti-cancer activity in preclinical osteosarcoma models and inhibited survival and proliferation of RCC cell lines and primary human RCC cells.