| 产品名称 | Lu AE58054 hydrochloride - Idalopirdine HCl |
| 产品货号 | Axon 2144 CAS [467458-02-2] MF C20H19F5N2O.HClMW 434.83 Purity: 100% Soluble in water and DMSO Description 5-HT6 receptor antagonist (Ki value 0.83 nM for h5-HT6) demonstrating >50-fold selectivity for more than 70 targets examined, with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Idalopirdine (Lu AE58054) potentiates the effects of Donepezil (Axon 1438) on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus. Note |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Lu AE58054 hydrochloride - Idalopirdine HClAxon 2144 CAS [467458-02-2] MF C20H19F5N2O.HCl
Description5-HT6 receptor antagonist (Ki value 0.83 nM for h5-HT6) demonstrating >50-fold selectivity for more than 70 targets examined, with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Idalopirdine (Lu AE58054) potentiates the effects of Donepezil (Axon 1438) on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus. Note: This item is currently suspended due to the concern of the IP right of the developer. You might request a quotation for contract research synthesis. Please contact us for conditions and more detailed information. KEYWORDS: Lu AE58054 hydrochloride | supplier | 5-HT6 antagonist | Idalopirdine HCl | LuAE58054 | CAS [467458-02-2] | [467459-31-0] | Serotonin | 5-HT6 | Antagonist | cognitive | schizophrenia | Donepezil | neuronal | oscillations | hippocampus
Selective 5-HT6 antagonist with good oral bioavailability
Chemical name2-(6-fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine hydrochloride Parent CAS No.[467459-31-0] |
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