产品名称

IITZ-01

产品货号

Axon 2933 CAS [1807988-47-1] MF C26H23FN8OMW 482.51 Purity: 99% Soluble in DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

IITZ-01

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2933

CAS [1807988-47-1]

MF C26H23FN8O
MW 482.51

Purity: 99%
Soluble in DMSO

Recently added

IITZ-01

Description

IITZ-01 is a potent lysosomotropic autophagy inhibitor which has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Screening against the growth of cancer cell lines MCF-7, MDAMB-231, PC-3, DU-145, HT-29 and HGC-27 gave IC50 values of 1.0 µM, 1.5 µM, 0.8 µM, 1.0 µM, 1.1 µM, 0.8 µM, respectively.

GJ Kumar et al. Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents. Medicinal Chemistry Research. December 2015, Volume 24, Issue 12, pp 3991–4001.

L Guntuku et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38(4):581-595.

Potent lysosomotropic autophagy inhibitor

Chemical name

N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine

Parent CAS No.

[1807988-47-1]

产品资料