产品名称

N106

产品货号

Axon 2565 CAS [862974-25-2] MF C17H14N4O3SMW 354.38 Purity: 99% Soluble in DMSO Description First-in-class small-molecule activator targeting E1 ligase mediated SERCA2a SUMOylation. N106 treatment increases contractile properties of cultured rat cardiomyocytes and significantly improves ventricular function in mice with heart failure. KEYWORDS: N106 | supplier | E1 ligase activator | N-106 | CAS [862974-25-2] | Ubiquitin | Ubiquitin Ligase (E1) | Activator | small ubiquitin-like modifier type 1 | SUMO-1 | SERCA2a | SUMOylation | heart failure | cardiomyocyte | cardiac | sarcoplasmic reticulum | calcium | ATPase

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

N106

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2565

CAS [862974-25-2]

MF C17H14N4O3S
MW 354.38

Purity: 99%
Soluble in DMSO

N106

Description

First-in-class small-molecule activator targeting E1 ligase mediated SERCA2a SUMOylation. N106 treatment increases contractile properties of cultured rat cardiomyocytes and significantly improves ventricular function in mice with heart failure.

KEYWORDS: N106 | supplier | E1 ligase activator | N-106 | CAS [862974-25-2] | Ubiquitin | Ubiquitin Ligase (E1) | Activator | small ubiquitin-like modifier type 1 | SUMO-1 | SERCA2a | SUMOylation | heart failure | cardiomyocyte | cardiac | sarcoplasmic reticulum | calcium | ATPase

C Kho et al. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat Commun. 2015 Jun 12;6:7229.

Apoptosis Cardiovascular Cell Signaling & Oncology Ubiquitin EC 6.3.2.19 Ubiquitin Ligase (E1)

Activator of E1 ligase mediated SERCA2a SUMOylation

Chemical name

N-(4-methoxybenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine

Parent CAS No.

[862974-25-2]

产品资料