| 产品名称 | TCID |
| 产品货号 | Axon 2333 CAS [30675-13-9] MF C9H2Cl4O2MW 283.92 Purity: 99% Soluble in DMSO Description Potent, cell permeant inhibitor of UCHL3 (IC50 value 0.6 µM) with 125-fold selectivity over UCHL1. Specific inhibition of UCHL3 with TCID diminished GlyT2 ubiquitination in brainstem and spinal cord primary neurons and may be beneficial in several human disorders, including neuromotor deficiencies (startle disease, myoclonus), pain and epilepsy. References Certificates Categories Extra info Y. Liu et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem. Biol. 2003, 10, 837-846. J. de Juan-Sanz et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013, 8, e58863. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Ubiquitin EC 3.4.19.12 Deubiquitinase Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 Chemical name 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione Parent CAS No. [30675-13-9] Order Size Unit Price Stock 10 mg €80.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
TCIDAxon 2333 CAS [30675-13-9] MF C9H2Cl4O2
Description
Potent, cell permeant inhibitor of UCHL3 (IC50 value 0.6 µM) with 125-fold selectivity over UCHL1. Specific inhibition of UCHL3 with TCID diminished GlyT2 ubiquitination in brainstem and spinal cord primary neurons and may be beneficial in several human disorders, including neuromotor deficiencies (startle disease, myoclonus), pain and epilepsy.
Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1
Chemical name4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione Parent CAS No.[30675-13-9] |
| 产品资料 |
