产品名称

ML364

产品货号

Axon 2678 CAS [1991986-30-1] MF C24H18F3N3O3S2MW 517.54 Purity: 99% Soluble in DMSO Description ML364, a small molecule inhibitor of the deubiquitinase USP2 (IC50 value of 1.1 μM), induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth. KEYWORDS: ML364 | supplier | USP2 inhibitor | ML 364 | ML-364 | CAS [1991986-30-1] | Non Selective (Ubiquitin peptides) | Deubiquitinase | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ML364

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2678

CAS [1991986-30-1]

MF C24H18F3N3O3S2
MW 517.54

Purity: 99%
Soluble in DMSO

ML364

Description

ML364, a small molecule inhibitor of the deubiquitinase USP2 (IC50 value of 1.1 μM), induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth.

MI Davis et al. Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models. J Biol Chem. 2016 Nov 18;291(47):24628-24640.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53-Tumor Suppression DNA-damage Response Ubiquitin EC 3.4.19.12 Deubiquitinase

Inhibitor of the deubiquitinase USP2

Chemical name

2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide

Parent CAS No.

[1991986-30-1]

产品资料