产品名称

AZ 628

产品货号

Axon 1545 CAS [878739-06-1] MF C27H25N5O2MW 451.52 Purity: 99% Soluble in DMSO Description Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF References Certificates Categories Extra info C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861. G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF B-Raf and C-Raf protein kinase inhibitor Chemical name 3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide Parent CAS No. [878739-06-1] Order Size Unit Price Stock 5 mg €80.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AZ 628

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1545

CAS [878739-06-1]

MF C27H25N5O2
MW 451.52

Purity: 99%
Soluble in DMSO

AZ 628

Description

Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF

C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861.

G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435.

B-Raf and C-Raf protein kinase inhibitor

Chemical name

3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide

Parent CAS No.

[878739-06-1]

产品资料