产品名称

GDC 0879

产品货号

Axon 1459 CAS [905281-76-7] MF C19H18N4O2MW 334.37 Purity: 99% Soluble in DMSO Description Selective inhibitor of protein kinase, targeting B-Raf (V600E) References Certificates Categories Extra info KP Hoeflich et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/MAPK pathway suppression. Cancer Res. 2009, 69(7), 3042-3051. H Wong et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor. J. Pharmacol. Exp. Ther. 2009, 329(1), 360-367. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF B-Raf protein kinase inhibitor Chemical name 5-[1-(2-Hydroxy-ethyl)-3-pyridin-4-yl-1H-pyrazol-4-yl]-indan-1-one oxime Parent CAS No. [905281-76-7] Order Size Unit Price Stock 2 mg €70.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GDC 0879

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1459

CAS [905281-76-7]

MF C19H18N4O2
MW 334.37

Purity: 99%
Soluble in DMSO

GDC 0879

Description

Selective inhibitor of protein kinase, targeting B-Raf (V600E)

KP Hoeflich et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/MAPK pathway suppression. Cancer Res. 2009, 69(7), 3042-3051.

H Wong et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor. J. Pharmacol. Exp. Ther. 2009, 329(1), 360-367.

B-Raf protein kinase inhibitor

Chemical name

5-[1-(2-Hydroxy-ethyl)-3-pyridin-4-yl-1H-pyrazol-4-yl]-indan-1-one oxime

Parent CAS No.

[905281-76-7]

产品资料