产品名称

Sorafenib tosylate - BAY 43-9006 | Nexavar

产品货号

Axon 1397 CAS [475207-59-1] MF C21H16ClF3N4O3.C7H8O3SMW 637.03 Purity: 99% Soluble in DMSO Description Small molecule inhibitor of protein kinase, targeting the Raf/Mek/Erk pathway References Certificates Categories Extra info DJ Panka et al. The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells. Cancer Res 2006, 66(3), 1611-1619. SM Wilhelm et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis. Cancer Res. 2004, 64, 7099-7109. SM Wilhelm et al. The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines. Proc. Am. Assoc. Cancer Res. 2003, 44, 106609. S. S. Sridhar et al. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005, 4, 677-685. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK PI3K-Akt-mTOR EC 2.7.11.1 RAF Protein kinase inhibitor of Raf/MEK/ERK pathway Chemical name 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide Parent CAS No. [284461-73-0] Order Size Unit Price Stock 10 mg €80.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Sorafenib tosylate - BAY 43-9006 | Nexavar

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1397

CAS [475207-59-1]

MF C21H16ClF3N4O3.C7H8O3S
MW 637.03

Purity: 99%
Soluble in DMSO

Sorafenib tosylate

Description

Small molecule inhibitor of protein kinase, targeting the Raf/Mek/Erk pathway

DJ Panka et al. The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells. Cancer Res 2006, 66(3), 1611-1619.

SM Wilhelm et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis. Cancer Res. 2004, 64, 7099-7109.

SM Wilhelm et al. The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines. Proc. Am. Assoc. Cancer Res. 2003, 44, 106609.

S. S. Sridhar et al. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005, 4, 677-685.

Protein kinase inhibitor of Raf/MEK/ERK pathway

Chemical name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

Parent CAS No.

[284461-73-0]

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