产品名称

R 406

产品货号

Axon 1674 CAS [841290-80-0] MF C22H23FN6O5MW 470.45 Purity: 98% Soluble in DMSO Description Orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) (Ki=30 nM). Active component of its prodrug R788 or R935788 (Fostamatinib) References Certificates Categories Extra info S Braselmann et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J. Pharmacol. Exp. Ther. 2006, 319(3), 998-1008. HS Cha et al. A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes. J. Pharmacol. Exp. Ther. 2006, 317(2), 571-578. JC Spalton et al. The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. J. Thromb. Haemost. 2009, 7, 1-8. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Spleen tyrosine kinase (Syk) EC 2.7.10.2 Spleen tyrosine kinase Inhibitor Chemical name 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Parent CAS No. [841290-80-0] Order Size Unit Price Stock 5 mg €95.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

R 406

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1674

CAS [841290-80-0]

MF C22H23FN6O5
MW 470.45

Purity: 98%
Soluble in DMSO

R 406

Description

Orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) (Ki=30 nM). Active component of its prodrug R788 or R935788 (Fostamatinib)

S Braselmann et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J. Pharmacol. Exp. Ther. 2006, 319(3), 998-1008.

HS Cha et al. A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes. J. Pharmacol. Exp. Ther. 2006, 317(2), 571-578.

JC Spalton et al. The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. J. Thromb. Haemost. 2009, 7, 1-8.

Spleen tyrosine kinase Inhibitor

Chemical name

6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

Parent CAS No.

[841290-80-0]

产品资料