| 产品名称 | Suprafenacine - SRF |
| 产品货号 | Axon 2398 CAS [1477482-50-0] MF C16H18N4OMW 282.34 Purity: 99% Soluble in DMSO Description Destabilizer of microtubules (IC50 value 0.38 µM for microtubule polymerization inhibition) that causes cell cycle arrest in the G2/M phase and cell death by apoptosis. Suprafenacine (SRF) was found to selectively inhibit cancer cell proliferation (IC50 values 83 - 381 nM in various cancer cell lines) and was effective against drug-resistant cancer cells by virtue of its ability to bypass the multidrug resistance transporter P-glycoprotein (P-gp). References Certificates Categories Extra info B.H. Choi et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One. 2014 Oct 29;9(10):e110955. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Tubulin Destabilizer of microtubules that causes cell cycle arrest in the G2/M phase Chemical name (E)-N'-(4-methylbenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide Parent CAS No. [1477482-50-0] Order Size Unit Price Stock 10 mg €110.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Suprafenacine - SRFAxon 2398 CAS [1477482-50-0] MF C16H18N4O
Description
Destabilizer of microtubules (IC50 value 0.38 µM for microtubule polymerization inhibition) that causes cell cycle arrest in the G2/M phase and cell death by apoptosis. Suprafenacine (SRF) was found to selectively inhibit cancer cell proliferation (IC50 values 83 - 381 nM in various cancer cell lines) and was effective against drug-resistant cancer cells by virtue of its ability to bypass the multidrug resistance transporter P-glycoprotein (P-gp).
Destabilizer of microtubules that causes cell cycle arrest in the G2/M phase
Chemical name(E)-N'-(4-methylbenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide Parent CAS No.[1477482-50-0] |
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