| 产品名称 | Remodelin |
| 产品货号 | Axon 2299 CAS [949912-58-7] MF C15H14N4SMW 282.36 Purity: 99% Soluble in DMSO Description Potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduced the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin had no effect on nonlaminopathic Werner syndrome cells References Certificates Categories Extra info D. Larrieu et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014, 344, 527-532. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response NAT 10 EC 2.3.1. Potent NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic cells via microtubule reorganization Chemical name 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile Parent CAS No. [949912-58-7] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
RemodelinAxon 2299 CAS [949912-58-7] MF C15H14N4S
Description
Potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduced the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin had no effect on nonlaminopathic Werner syndrome cells
Potent NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic cells via microtubule reorganization
Chemical name4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile Parent CAS No.[949912-58-7] |
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