| 产品名称 | Gallic acid - NSC 674319 |
| 产品货号 | Axon 2208 CAS [149-91-7] MF C7H6O5MW 170.12 Purity: 100% Soluble in water and DMSO Description Multi-affinity drug. Targets Carbonic Anhydrases, FUT7, P4H, HATs, among many others in an inhibitory modus. Gallic acid is cytotoxic to cancer cells and has anti-inflammatory and antioxidative effects. Gallic acid was found to inhibit the histone acetyltransferase activity of several HATs (IC50 values: 14, 24, 25 and 34 μM for p300, CBP, Tip60 and PCAF respectively). In particular, it inhibited p300/CBP-dependent HAT activities uncompetitively, while being devoid of activity towards other epigenetic enzymes including SIRT1, HDAC, and HMTase. In A549 lung cancer cells, Gallic acid inhibited the acetylation of p65, leading to the downregulation of NF-κB activation in response to diverse inflammatory signals.Gallic acid is also known to inhibit HIV-1 infections through inhibition of HIV-1 reverse transcriptase activity in Lagerstroemia speciosa L. References Certificates Categories Extra info A. Innocenti et al. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I–XIV with a series of natural product polyphenols and phenolic acids. Bioorg. Med. Chem. 2010, 18, 2159–2164. K.C. Choi. Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cells. Mol. Cancer Res. 2009, 12, 2011-2021. K. Majamaa et al. Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. J. Biol. Chem. 1986, 261, 7819-7823. S. Madlener et al. Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells. Cancer. Lett. 2007, 245, 156–162. X. Niu et al. Inhibition of fucosyltransferase VII by gallic acid and its derivatives. Arch. Biochem. Biophys. 2004, 425, 51-57. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation Carbonic Anhydrase HAT RT NF-κB EC 2.3.1.48 Multi-affinity drug. Antioxidant. Chemical name 3,4,5-trihydroxybenzoic acid Parent CAS No. [149-91-7] Order Size Unit Price Stock 100 mg €50.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Gallic acid - NSC 674319Axon 2208 CAS [149-91-7] MF C7H6O5
Description
Multi-affinity drug. Targets Carbonic Anhydrases, FUT7, P4H, HATs, among many others in an inhibitory modus. Gallic acid is cytotoxic to cancer cells and has anti-inflammatory and antioxidative effects. Gallic acid was found to inhibit the histone acetyltransferase activity of several HATs (IC50 values: 14, 24, 25 and 34 μM for p300, CBP, Tip60 and PCAF respectively). In particular, it inhibited p300/CBP-dependent HAT activities uncompetitively, while being devoid of activity towards other epigenetic enzymes including SIRT1, HDAC, and HMTase. In A549 lung cancer cells, Gallic acid inhibited the acetylation of p65, leading to the downregulation of NF-κB activation in response to diverse inflammatory signals.Gallic acid is also known to inhibit HIV-1 infections through inhibition of HIV-1 reverse transcriptase activity in Lagerstroemia speciosa L.
Multi-affinity drug. Antioxidant.
Chemical name3,4,5-trihydroxybenzoic acid Parent CAS No.[149-91-7] |
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