Solithromycin - CEM 101 | OP 1068

Based on 131 publications in PubMed 9 10 131

Axon 2606

CAS [760981-83-7]

MF C43H65FN6O10
MW 845.01

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Solithromycin

Description

Fluoroketolide antibiotic with reported high potency against diverse groups of Gram-positive and Gram-negative bacteria (MIC50 values 0.015 μg/mL and 4 μg/mL, respectively). Solithromycin (CEM-101 or OP-1068) binds to multiple sites of the bacterial large ribosomal subunit (23S rRNA) near the ribosomal exit tunnel.

S Lemaire et al. Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and ... Antimicrob Agents Chemother. 2009 Sep;53(9):3734-43.

P McGhee et al. In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Antimicrob Agents Chemother. 2010 Jan;54(1):230-8.

SD Putnam et al. CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria. Diagn Microbiol Infect Dis. 2010 Apr;66(4):393-401.

B Llano-Sotelo et al. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother. 2010 Dec;54(12):4961-70.

Fluoroketolide antibiotic

Chemical name

(1R,2R,4R,6R,7R,8R,10S,13R,14S)-17-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-10-fluoro-6-methoxy-2,4,6,8,10,14-hexamethyl-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tet

Parent CAS No.

[760981-83-7]

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