产品名称

BCI - NSC 150117

产品货号

Axon 2178 CAS [1245792-51-1] MF C22H23NOMW 317.42 Purity: 99% Soluble in DMSO Description Allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc–transfected cells blocks DUSP6 or DUSP1 activity, but not DUSP5 (IC50 values 12.3 μM and 11.5 μM for DUSP6 and DUSP1 inhibition, resp.). BCI mediated DUSP6 inhibition can induce expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos.BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM).The dual-specificity phosphatase 6 (DUSP6) functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2. The more hydrophilic BCI hydrochloride (Axon 2852) is also available. KEYWORDS: BCI | supplier | DUSP inhibitor | NSC 150117 | NSC150117 | NSC-150117 | CAS [1245792-51-1] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | DUSP | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BCI - NSC 150117

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2178

CAS [1245792-51-1]

MF C22H23NO
MW 317.42

Purity: 99%
Soluble in DMSO

BCI

Description

Allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc–transfected cells blocks DUSP6 or DUSP1 activity, but not DUSP5 (IC50 values 12.3 μM and 11.5 μM for DUSP6 and DUSP1 inhibition, resp.). BCI mediated DUSP6 inhibition can induce expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos.BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM).The dual-specificity phosphatase 6 (DUSP6) functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.

The more hydrophilic BCI hydrochloride (Axon 2852) is also available.

G. Molina et al. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat. Chem. Biol. 2009, 5, 680-687.

A.M. Best et al. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. J. Biomed. Biotechnol. 2011, 868095.

Angiogenesis Apoptosis Cardiovascular Cell Signaling & Oncology Epigenetics NF-κB MAPK EC 3.1.3.16 DUSP

Allosteric inhibitor of dual-specificity phosphatases (DUSP)

Chemical name

2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one

Parent CAS No.

[1245792-51-1]

产品资料