产品名称

KYA1797K

产品货号

Axon 2668 CAS [1956356-56-1] MF C17H11KN2O6S2MW 442.51 Purity: 99% Soluble in DMSO Description Promotor of β-catenin and Ras degradation (IC50 value 0.75 μM for inhibition of TOPflash activity) that effectively suppresses the growth of CRCs (colorectal cancers) harboring APC and KRAS mutations in vitro and in vivo. KYA1797K binds the RGS domain of axin and enhances the binding affinity of β-catenin or Ras with the β-catenin destruction complex components, leading to simultaneous destabilization of β-catenin and Ras via GSK3β activation. KYA1797 also inhibits ASK1 (IC50 value 0.65 μM for inhibition of apoptosis signal-regulating kinase 1). KEYWORDS: KYA1797K | supplier | dual ASK1 and Wnt/β-catenin inhibitor | KYA 1797K | CAS [1956356-56-1] | [ 851304-36-4] | Wnt Inhibitor | Axin | Axin1 | RGS domain | Ras | GSK3β activation | ASK1 | apoptosis signal-regulating kinase 1 | colorectal cancer | CRC | APC

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

KYA1797K

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2668

CAS [1956356-56-1]

MF C17H11KN2O6S2
MW 442.51

Purity: 99%
Soluble in DMSO

KYA1797K

Description

Promotor of β-catenin and Ras degradation (IC50 value 0.75 μM for inhibition of TOPflash activity) that effectively suppresses the growth of CRCs (colorectal cancers) harboring APC and KRAS mutations in vitro and in vivo. KYA1797K binds the RGS domain of axin and enhances the binding affinity of β-catenin or Ras with the β-catenin destruction complex components, leading to simultaneous destabilization of β-catenin and Ras via GSK3β activation. KYA1797 also inhibits ASK1 (IC50 value 0.65 μM for inhibition of apoptosis signal-regulating kinase 1).