| 产品名称 | ADAMTS-5 inhibitor - Compound 12 |
| 产品货号 | Axon 2083 CAS [929634-33-3] MF C16H11ClF3N3OS3MW 449.92 Purity: 100% Soluble in 0.1N NaOH(aq) and DMSO Description Inhibitor of ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5 or aggrecanase-2; IC50 1.1 μM) with >40-fold functional selectivity over ADAMTS-4. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA). References Certificates Categories Extra info A.M. Gilbert et al. 5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg. Med. Chem. Lett. 2007, 17, 1189–1192. J. Bondeson et al. The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review. Clin. Exp. Rheumatol. 2008, 26, 139-145. Certificate of Analysis Material Safety Data Sheet Pain & Inflammation ADAMTS-5 EC 3.4.24 Selective inhibitor of ADAMTS-5 (aggrecanase-2) Chemical name (Z)-5-((5-(4-chlorobenzylthio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one Parent CAS No. [929634-33-3] Order Size Unit Price Stock 5 mg €135.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
ADAMTS-5 inhibitor - Compound 12Axon 2083 CAS [929634-33-3] MF C16H11ClF3N3OS3
Description
Inhibitor of ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5 or aggrecanase-2; IC50 1.1 μM) with >40-fold functional selectivity over ADAMTS-4. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA).
Selective inhibitor of ADAMTS-5 (aggrecanase-2)
Chemical name(Z)-5-((5-(4-chlorobenzylthio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one Parent CAS No.[929634-33-3] |
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