| 产品名称 | SIS3 - Smad3 inhibitor SIS3 |
| 产品货号 | Axon 2764 CAS [521985-36-4] MF C28H27N3O3MW 453.53 Purity: 98% Soluble in DMSO Description SIS3 is a potent and selective inhibitor of Smad3 and TGF-β signaling. Inhibition by SIS3 leads to abrogation of the TGF-β1-induced production of extracellular matrix proteins in normal fibroblasts and scleroderma fibroblasts. Moreover, Smad3 inhibition attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells. KEYWORDS: SIS3 | supplier | Smad3 inhibitor | Smad3 inhibitor SIS3 | SIS-3 | SIS 3 | CAS [521985-36-4] | DNA-RNA | Smad3 | Inhibitor | Transcription Factors | TGF-β | Breast Cancer | HER2 |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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SIS3 - Smad3 inhibitor SIS3Axon 2764 CAS [521985-36-4] MF C28H27N3O3
DescriptionSIS3 is a potent and selective inhibitor of Smad3 and TGF-β signaling. Inhibition by SIS3 leads to abrogation of the TGF-β1-induced production of extracellular matrix proteins in normal fibroblasts and scleroderma fibroblasts. Moreover, Smad3 inhibition attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells. KEYWORDS: SIS3 | supplier | Smad3 inhibitor | Smad3 inhibitor SIS3 | SIS-3 | SIS 3 | CAS [521985-36-4] | DNA-RNA | Smad3 | Inhibitor | Transcription Factors | TGF-β | Breast Cancer | HER2
Potent and selective inhibitor of Smad3 and TGF-βR1 signaling
Chemical name(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Parent CAS No.[521985-36-4] |
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