产品名称

R 428 dihydrochloride - BGB324 | Bemcentinib

产品货号

Axon 1946 CAS [N.A.] MF C30H34N8.2HClMW 579.57 Purity: 99% Optical purity: 99% ee Soluble in water and DMSO Description Potent and selective inhibitor of Axl receptor tyrosine kinases (IC50: 14 nM); R428 inhibits Axl kinase and blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Note: The hydrochloride salt of R428 is water-soluble and has an improved solubility in DMSO in comparison with its free base KEYWORDS: R 428 dihydrochloride | supplier | Axl inhibitor | BGB324 | R428 HCl | R-428 | BGB-324 | CAS [1037624-75-1] | Gas6 | Axl | receptor tyrosine kinase | RTK | Akt | breast cancer | proinflammatory | cytokine production

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

R 428 dihydrochloride - BGB324 | Bemcentinib

Based on 160 publications in PubMed 10 10 160

Axon 1946

CAS [N.A.]

MF C30H34N8.2HCl
MW 579.57

Purity: 99%
Optical purity: 99% ee
Soluble in water and DMSO

R 428 dihydrochloride

Description

Potent and selective inhibitor of Axl receptor tyrosine kinases (IC50: 14 nM); R428 inhibits Axl kinase and blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.

Note: The hydrochloride salt of R428 is water-soluble and has an improved solubility in DMSO in comparison with its free base

KEYWORDS: R 428 dihydrochloride | supplier | Axl inhibitor | BGB324 | R428 HCl | R-428 | BGB-324 | CAS [1037624-75-1] | Gas6 | Axl | receptor tyrosine kinase | RTK | Akt | breast cancer | proinflammatory | cytokine production

SJ Holland et al. R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer. Cancer Res. 2010, 70, 1544.

Ghosh AK et al. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood, 2011, 117(6), 1928-37.

GX Ruan and A Kazlauskas. Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J. 2012, 31(7), 1692-1703.

Cell Signaling & Oncology Pain & Inflammation Axl RTK class XI; EC 2.7.10.1

Selective inhibitor of Axl receptor tyrosine kinases

Chemical name

1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazine-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]- dihydrochloride

Parent CAS No.

[1037624-75-1]

产品资料