产品名称

Ensemble Compound 159

产品货号

Axon 2800 CAS [1449208-36-9] MF C42H51ClN6O6MW 771.34 Purity: 97% Optical purity: Optically pure Description Ensemble Compound 159 is a peptide inhibitor of IL-17A. Ensemble Compound 159 binds to IL-17A and/or inhibits formation of the IL-17A–IL-17RA complex through an ELISA assay, an HT29-GROα cell based functional assay, a rheumatoid arthritis synovial fibroblast (RASF) assay, and surface plasmon resonance (SPR, Kd < 100 nM) based biophysical binding assessment. Moreover, Ensemble Compound 159 was reported to have efficacy in vivo. KEYWORDS: Ensemble Compound 159 | supplier | IL-17A inhibitor | Cp159 | Cp-159 | Cp 159 | CAS [1449208-36-9] | Interleukin | IL-17 | Inhibitor

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Ensemble Compound 159

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2800

CAS [1449208-36-9]

MF C42H51ClN6O6
MW 771.34

Purity: 97%
Optical purity: Optically pure

Ensemble Compound 159

Description

Ensemble Compound 159 is a peptide inhibitor of IL-17A. Ensemble Compound 159 binds to IL-17A and/or inhibits formation of the IL-17A–IL-17RA complex through an ELISA assay, an HT29-GROα cell based functional assay, a rheumatoid arthritis synovial fibroblast (RASF) assay, and surface plasmon resonance (SPR, Kd < 100 nM) based biophysical binding assessment. Moreover, Ensemble Compound 159 was reported to have efficacy in vivo.

KEYWORDS: Ensemble Compound 159 | supplier | IL-17A inhibitor | Cp159 | Cp-159 | Cp 159 | CAS [1449208-36-9] | Interleukin | IL-17 | Inhibitor

A Espada et al. A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry. J Med Chem. 2016 Mar 10;59(5):2255-60.

Cell Signaling & Oncology Immunology Miscellaneous Pain & Inflammation Transcription Factors NF-κB MAPK IL-17 IL 17 family

Cytokine inhibitor; IL-17A inhibitor

Chemical name

(2S)-3-(2-chlorophenyl)-2-(2-phenylacetamido)-N-(4-(((9R)-7,10,13,21-tetraoxo-8,11,14,20-tetraazaspiro[4.17]docosan-9-yl)methyl)phenyl)propanamide

Parent CAS No.

[1449208-36-9]

产品资料