产品名称

UNC 569

产品货号

Axon 2086 CAS [1350547-65-7] MF C22H29FN6MW 396.50 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (RTK) (IC50: 2.9 nM). UNC 569 inhibits Mer activation and downstream signaling through ERK1/2 and AKT and was capable of inducing >50% reduction in tumor burden compared to references. Potential therapeutic for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors (ATRT). KEYWORDS: UNC 569 | supplier | Mer Inhibitor | UNC569 | CAS [1350547-65-7] | Gas6 | Mer | Inhibitor | Receptors | RTK

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

UNC 569

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2086

CAS [1350547-65-7]

MF C22H29FN6
MW 396.50

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

UNC 569

Description

Potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (RTK) (IC50: 2.9 nM). UNC 569 inhibits Mer activation and downstream signaling through ERK1/2 and AKT and was capable of inducing >50% reduction in tumor burden compared to references. Potential therapeutic for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors (ATRT).

KEYWORDS: UNC 569 | supplier | Mer Inhibitor | UNC569 | CAS [1350547-65-7] | Gas6 | Mer | Inhibitor | Receptors | RTK

S Christoph et al. UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol. Cancer Ther. 2013, Aug 30, [Epub ahead of print].

J Liu et al. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. Med. Chem. Lett. 2012, 3, 129-134.

Angiogenesis Cell Signaling & Oncology Pain & Inflammation Mer RTK class XI; EC 2.7.10.1

Reversible and ATP-competitive inhibitor of Mer (RTK)

Chemical name

1-((trans-4-aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

Parent CAS No.

[1350547-65-7]

产品资料