产品名称

AR-42

产品货号

Axon 2394 CAS [935881-37-1] MF C18H20N2O3MW 312.36 Purity: 99% Optical purity: optically pure Soluble in DMSO Description AR-42 is a novel HDAC inhibitor (IC50 value of 16 nM) with potent anticancer effects in pancreatic cancer cells at submicromolar concentrations by inducing cell cycle arrest, stimulating apoptosis, and regulating expression of several miRNAs. Also demonstrated anticancer activity in many other cancers, including acute myeloid leukemia, multiple myeloma, prostate cancer, ovarian cancer, human glioma cells, and bladder cancer. KEYWORDS: AR-42 | supplier | HDAC inhibitor | AR 42 | AR42 | CAS [935881-37-1] | Histone | HDAC | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AR-42

Based on 47 reference(s) in Google Scholar 8 10 47

Axon 2394

CAS [935881-37-1]

MF C18H20N2O3
MW 312.36

Purity: 99%
Optical purity: optically pure
Soluble in DMSO

AR-42

Description

AR-42 is a novel HDAC inhibitor (IC50 value of 16 nM) with potent anticancer effects in pancreatic cancer cells at submicromolar concentrations by inducing cell cycle arrest, stimulating apoptosis, and regulating expression of several miRNAs. Also demonstrated anticancer activity in many other cancers, including acute myeloid leukemia, multiple myeloma, prostate cancer, ovarian cancer, human glioma cells, and bladder cancer.

Q Lu et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.

YJ Chen et al. Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways. PLoS One. 2017 Aug 22;12(8):e0183368.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC

HDAC inhibitor

Chemical name

(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide

Parent CAS No.

[935881-37-1]

产品资料