| 产品名称 | LW 479 |
| 产品货号 | Axon 2430 CAS [1688677-89-5] MF C21H23BrN2O4SMW 479.39 Purity: 98% Soluble in DMSO Description HDAC inhibitor that shows marked cytotoxicity and induces apoptosis as well as cell cycle arrest in a panel of breast cancer cell lines. LW479 silences EGFR expression in breast cancer cells through disrupting Sp1 and HDAC1 binding to EGFR promoter, and blocks EGF/EGFR signalling pathway and EGF-stimulated motility. Moreover, LW-479 attenuates breast cancer metastasis to the lung. References Certificates Categories Extra info J. Li et al. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression. Br J Pharmacol. 2015 Aug;172(15):3817-30. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC HDAC inhibitor with cytotoxicity in a panel of breast cancer cell lines. Chemical name 6-(2-(2-(3-bromophenyl)-4-oxothiazolidin-3-yl)phenoxy)-N-hydroxyhexanamide Parent CAS No. [1688677-89-5] Order Size Unit Price Stock 10 mg €135.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
LW 479Axon 2430 CAS [1688677-89-5] MF C21H23BrN2O4S
Description
HDAC inhibitor that shows marked cytotoxicity and induces apoptosis as well as cell cycle arrest in a panel of breast cancer cell lines. LW479 silences EGFR expression in breast cancer cells through disrupting Sp1 and HDAC1 binding to EGFR promoter, and blocks EGF/EGFR signalling pathway and EGF-stimulated motility. Moreover, LW-479 attenuates breast cancer metastasis to the lung.
HDAC inhibitor with cytotoxicity in a panel of breast cancer cell lines.
Chemical name6-(2-(2-(3-bromophenyl)-4-oxothiazolidin-3-yl)phenoxy)-N-hydroxyhexanamide Parent CAS No.[1688677-89-5] |
| 产品资料 |
