产品名称

HDAC6 inhibitor ISOX

产品货号

Axon 1645 CAS [1045792-66-2] MF C22H30N4O6MW 446.50 Purity: 99% Soluble in DMSO Description Potent and selective histone deacetylase 6 (HDAC6) inhibitor, with IC50 to be 2.4 nM (HDAC6) and 71 nM (HDAC1). (*2010 revised affinities). KEYWORDS: HDAC6 inhibitor ISOX | supplier | HDAC6 inhibitor | ISOX | CAS [1045792-66-2] | Histone | HDAC | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

HDAC6 inhibitor ISOX

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1645

CAS [1045792-66-2]

MF C22H30N4O6
MW 446.50

Purity: 99%
Soluble in DMSO

HDAC6 inhibitor ISOX

Description

Potent and selective histone deacetylase 6 (HDAC6) inhibitor, with IC50 to be 2.4 nM (HDAC6) and 71 nM (HDAC1). (*2010 revised affinities).

KEYWORDS: HDAC6 inhibitor ISOX | supplier | HDAC6 inhibitor | ISOX | CAS [1045792-66-2] | Histone | HDAC | Inhibitor | Enzymes

KV Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A. J. Am. Chem. Soc. 2010, 132, 10842–10846.

AP Kozikowski et al. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6. J. Med. Chem. 2008, 51, 4370–4373.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC

HDAC6 Inhibitor

Chemical name

tert-butyl 4-(3-(7-(hydroxyamino)-7-oxoheptylcarbamoyl)isoxazol-5-yl)phenylcarbamate

Parent CAS No.

[1045792-66-2]

产品资料