产品名称

WZ 4003

产品货号

Axon 2385 CAS [1214265-58-3] MF C25H29ClN6O3MW 496.99 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Specific dual inhibitor of NUAK1 (aka ARK5) and NUAK2 (aka SNARK; IC50 values 20 nM and 100 nM, respectively) with no significant inhibitory effect on a panel of 139 other kinases tested, including ten other AMPK-related kinases. WZ4003 suppressed MYPT1 phosphorylation in a dose-dependent manner, and inhibited cell proliferation, invasion and migration in vivo. Although WZ 4003 is a close analogue of WZ 4002 (Axon 1506), it shows no affinity for the EGFR (Kd value 14 µM) References Certificates Categories Extra info S. Banerjee et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25. W Zhou et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462, 1070-1074. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 NUAK Specific dual inhibitor of NUAK1 (ARK5) and NUAK2 (SNARK) Chemical name N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)propionamide Parent CAS No. [1214265-58-3] Order Size Unit Price Stock 5 mg €90.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

WZ 4003

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2385

CAS [1214265-58-3]

MF C25H29ClN6O3
MW 496.99

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

WZ 4003

Description

Specific dual inhibitor of NUAK1 (aka ARK5) and NUAK2 (aka SNARK; IC50 values 20 nM and 100 nM, respectively) with no significant inhibitory effect on a panel of 139 other kinases tested, including ten other AMPK-related kinases. WZ4003 suppressed MYPT1 phosphorylation in a dose-dependent manner, and inhibited cell proliferation, invasion and migration in vivo.
Although WZ 4003 is a close analogue of WZ 4002 (Axon 1506), it shows no affinity for the EGFR (Kd value 14 µM)

S. Banerjee et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.

W Zhou et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462, 1070-1074.

Specific dual inhibitor of NUAK1 (ARK5) and NUAK2 (SNARK)

Chemical name

N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)propionamide

Parent CAS No.

[1214265-58-3]

产品资料