| 产品名称 | ZLN 024 |
| 产品货号 | Axon 2445 CAS [723249-01-2] MF C13H13BrN2OSMW 325.22 Purity: 100% Soluble in DMSO Description Allosteric activator of AMP-activated protein kinase (AMPK; EC50 values 0.42 µM and 0.95 µM for increasing the activity of activated heterotrimers α1β1γ1 and α2β1γ1, respectively) that has no effect on mitochondrial function or the ADP/ATP ratio, and which exerts beneficial metabolic effects in vitro and in vivo. ZLN 024 reduced glucose intolerance and fatty liver characteristics in diabetic db/db mice and provides a promising therapeutic approach for type 2 diabetes mellitus and metabolic syndrome. References Certificates Categories Extra info L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Diabetes & Metabolism Epigenetics Stem Cell AMPK TGF-β MAPK PI3K-Akt-mTOR EC 2.7.11.31 Allosteric activator of AMP-activated protein kinase (AMPK) Chemical name 2-(2-(2-bromo-4-methylphenoxy)ethylthio)pyrimidine Parent CAS No. [723249-01-2] Order Size Unit Price Stock 10 mg €90.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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ZLN 024Axon 2445 CAS [723249-01-2] MF C13H13BrN2OS
DescriptionAllosteric activator of AMP-activated protein kinase (AMPK; EC50 values 0.42 µM and 0.95 µM for increasing the activity of activated heterotrimers α1β1γ1 and α2β1γ1, respectively) that has no effect on mitochondrial function or the ADP/ATP ratio, and which exerts beneficial metabolic effects in vitro and in vivo. ZLN 024 reduced glucose intolerance and fatty liver characteristics in diabetic db/db mice and provides a promising therapeutic approach for type 2 diabetes mellitus and metabolic syndrome.
Allosteric activator of AMP-activated protein kinase (AMPK)
Chemical name2-(2-(2-bromo-4-methylphenoxy)ethylthio)pyrimidine Parent CAS No.[723249-01-2] |
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