产品名称

WAY-200070 - WAY-00005

产品货号

Axon 2697 CAS [440122-66-7] MF C13H8BrNO3MW 306.11 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Brain penetrant ERβ-selective agonist (IC50 values 155 nM and 2 nM for ERα and ERβ, respectively) that increases key synaptic proteins in vivo, including PSD-95, synaptophysin and the AMPA-receptor subunit GluR1 and increases dendritic branching and spine number. WAY 20070 regulates hippocampal synaptic plasticity and improve hippocampus-dependent cognition, and shows antidepressant and anxiolytic-like effects in vivo. Potential novel therapeutic agent for the prevention and treatment of photoaging. KEYWORDS: WAY-200070 | supplier | ERβ agonist | WAY-00005 | WAY200070 | WAY 200070 | WAY00005 | WAY 00005 | CAS [440122-66-7] | Axon Medchem | Axon 2697 | Estrogen | Nuclear Receptor | Brain penetrant | PSD-95 | synaptophysin | AMPA | GluR1 | dendritic branching | synaptic plasticity | cognition | antidepressant | anxiolytic

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

WAY-200070 - WAY-00005

Based on 56 publications in PubMed 8 10 56

Axon 2697

CAS [440122-66-7]

MF C13H8BrNO3
MW 306.11

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

WAY-200070

Description

Brain penetrant ERβ-selective agonist (IC50 values 155 nM and 2 nM for ERα and ERβ, respectively) that increases key synaptic proteins in vivo, including PSD-95, synaptophysin and the AMPA-receptor subunit GluR1 and increases dendritic branching and spine number. WAY 20070 regulates hippocampal synaptic plasticity and improve hippocampus-dependent cognition, and shows antidepressant and anxiolytic-like effects in vivo. Potential novel therapeutic agent for the prevention and treatment of photoaging.

KEYWORDS: WAY-200070 | supplier | ERβ agonist | WAY-00005 | WAY200070 | WAY 200070 | WAY00005 | WAY 00005 | CAS [440122-66-7] | Axon Medchem | Axon 2697 | Estrogen | Nuclear Receptor | Brain penetrant | PSD-95 | synaptophysin | AMPA | GluR1 | dendritic branching | synaptic plasticity | cognition | antidepressant | anxiolytic

JK Gill et al. Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci USA. 2011 Apr 5;108(14):5867-72.

RL Papke. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. J Biol Chem. 2014 Feb 14;289(7):4515-31.

Cell Signaling & Oncology CNS Endocrinology Estrogen (ER) NR3A

Brain penetrant ERβ-selective agonist

Chemical name

7-bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol

Parent CAS No.

[440122-66-7]

产品资料