| 产品名称 | ITD-1, (+)- |
| 产品货号 | Axon 2467 CAS [1409968-46-2] MF C27H29NO3MW 415.52 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description More active (+)-enantiomer of ITD 1 (Axon 2323), a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that acts by clearing the type II TGFβ receptor from the cell surface. ITD 1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-enantiomer is approximately 15-fold more effective than by its (−)-enantiomer. KEYWORDS: (+)-ITD-1 | supplier | TGF-βR2 inhibitor | ITD1 | (+)-ITD1 | CAS [1409968-46-2] | [1099644-42-4] | [1217467-13-4] | TGF-β | TGF-βR | Antagonist | active enantiomer | Smad | differentiation | cardiomyocytes | cardiogenesis | mESC | stem cell |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
ITD-1, (+)-Axon 2467 CAS [1409968-46-2] MF C27H29NO3
DescriptionMore active (+)-enantiomer of ITD 1 (Axon 2323), a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that acts by clearing the type II TGFβ receptor from the cell surface. ITD 1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-enantiomer is approximately 15-fold more effective than by its (−)-enantiomer. KEYWORDS: (+)-ITD-1 | supplier | TGF-βR2 inhibitor | ITD1 | (+)-ITD1 | CAS [1409968-46-2] | [1099644-42-4] | [1217467-13-4] | TGF-β | TGF-βR | Antagonist | active enantiomer | Smad | differentiation | cardiomyocytes | cardiogenesis | mESC | stem cell
Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis
Chemical name(R)-ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate Parent CAS No.[1409968-46-2] |
| 产品资料 |
