| 产品名称 | CCT 031374 hydrobromide |
| 产品货号 | Axon 2161 CAS [1219184-91-4] MF C23H19N3O.HBrMW 434.33 Purity: 98% Soluble in DMSO Description Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway with in vivo activity in SW480 colon cancer cells (IC50 of 6.1 μM in a HEK293-based reporter cell line). CCT 031374 acts at the β-catenin level based on the observation that it blocked the nuclear β-catenin/transcription factor (TCF) transcription complex dependent transcription induced by a stabilized form of β-catenin, but not by a constitutively active TCF-VP16 fusion protein. References Certificates Categories Extra info K. Ewan et al. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 2010, 70, 5963-5673. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Wnt Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway Chemical name 1-biphenyl-4-yl-2-(2,3-dihydro-benzo[d]imidazo[1,2-a]imidazol-9-yl)-ethanone hydrobromide Parent CAS No. [442535-46-8] Order Size Unit Price Stock 2 mg €60.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
CCT 031374 hydrobromideAxon 2161 CAS [1219184-91-4] MF C23H19N3O.HBr
Description
Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway with in vivo activity in SW480 colon cancer cells (IC50 of 6.1 μM in a HEK293-based reporter cell line). CCT 031374 acts at the β-catenin level based on the observation that it blocked the nuclear β-catenin/transcription factor (TCF) transcription complex dependent transcription induced by a stabilized form of β-catenin, but not by a constitutively active TCF-VP16 fusion protein.
Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway
Chemical name1-biphenyl-4-yl-2-(2,3-dihydro-benzo[d]imidazo[1,2-a]imidazol-9-yl)-ethanone hydrobromide Parent CAS No.[442535-46-8] |
| 产品资料 |
