产品名称

FH535

产品货号

Axon 2686 CAS [108409-83-2] MF C13H10Cl2N2O4SMW 361.20 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706. KEYWORDS: FH535 | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 | FH 535 | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

FH535

Based on 94 publications in PubMed 10 10 94

Axon 2686

CAS [108409-83-2]

MF C13H10Cl2N2O4S
MW 361.20

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

FH535

Description

Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706.