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产品名称 ISRIB - trans-ISRIB
产品货号 Axon 2278 CAS [1597403-47-8] MF C22H24Cl2N2O4MW 451.34 Purity: 99% Optical purity: Relative stereochemistry Soluble in DMSO and DCM-MeOH Description First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter).Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific. References Certificates Categories Extra info C. Sidrauski et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife 2013, 2, e00498.   A.G. Hinnebusch et al. Cell biology. Blocking stress response for better memory? Science. 2015 May 29;348(6238):967-8. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology CNS PERK EC 2.7.11.1 Potent inhibitor of the integrated stress response and PERK signaling Chemical name N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) Parent CAS No. [1597403-47-8] Order Size Unit Price Stock 10 mg €95.00 In Stock
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ISRIB - trans-ISRIB

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2278

CAS [1597403-47-8]

MF C22H24Cl2N2O4
MW 451.34

  • Purity: 99%
  • Optical purity: Relative stereochemistry
  • Soluble in DMSO and DCM-MeOH

ISRIB

Description

First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter).Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific.
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