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产品名称 ZLN 005
产品货号 Axon 2379 CAS [49671-76-3] MF C17H18N2MW 250.34 Purity: 99% Soluble in DMSO Description Selective transcriptional regulator of peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type–specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle. References Certificates Categories Extra info L.N. Zhang et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013, 62, 1297-1307.   L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013, 8, e72092.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism Transcription Factors PGC PPARGC1A Selective transcriptional regulator of peroxisome PPAR-γ coactivator-1α (PGC-1α). Chemical name 2-(4-tert-butylphenyl)-1H-benzo[d]imidazole Parent CAS No. [49671-76-3] Order Size Unit Price Stock 10 mg €45.00 In Stock
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ZLN 005

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2379

CAS [49671-76-3]

MF C17H18N2
MW 250.34

  • Purity: 99%
  • Soluble in DMSO

ZLN 005

Description

Selective transcriptional regulator of peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type–specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle.
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