产品名称

ICG 001

产品货号

Axon 1766 CAS [847591-62-2] MF C33H32N4O4MW 548.63 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Specific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer References Certificates Categories Extra info KH Emami et al. A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription. PNAS 2004, 101(34), 12682-12687. M Eguchi et al. ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Med. Chem. 2005, 1(5), 467-472. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Cell-Cell Adhesion Protein Wnt Specific inhibitor of Wnt/β-catenin signaling pathway Chemical name (6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrimido[1,2-a]pyrazine-1-carboxamide Parent CAS No. [780757-88-2 (relative stereochemistry; Scifinder names incorrectly) 847591-62-2 (absolute stereochemistry)] Order Size Unit Price Stock 5 mg €115.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ICG 001

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1766

CAS [847591-62-2]

MF C33H32N4O4
MW 548.63

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

ICG 001

Description

Specific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer

KH Emami et al. A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription. PNAS 2004, 101(34), 12682-12687.

M Eguchi et al. ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Med. Chem. 2005, 1(5), 467-472.

Apoptosis Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Cell-Cell Adhesion Protein Wnt

Specific inhibitor of Wnt/β-catenin signaling pathway

Chemical name

(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrimido[1,2-a]pyrazine-1-carboxamide

Parent CAS No.

[780757-88-2 (relative stereochemistry; Scifinder names incorrectly) 847591-62-2 (absolute stereochemistry)]

产品资料