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产品名称 Genz 644282
产品货号 Axon 2198 CAS [529488-28-6] MF C22H21N3O5MW 407.42 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Topoisomerase I inhibitor (IC50 value 0.4 nM in human bone marrow CFU-GM assay). Cytotoxic agent, with activity toward 8 human tumor cell lines of varied histology and resistance mechanisms by colony formation, with enhanced potency compared to topotecan and SN-38. Contrary to the camptothecins, Genz-644282 is not a substrate for the multidrug resistance gene 1 (MDR1) and breast cancer resistance protein (BCRP) efflux pumps. References Certificates Categories Extra info L.S. Kurtzberg et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin. Cancer Res. 2011, 17, 2777-2787.    P.J. Houghton et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr. Blood Cancer. 2012, 58, 200-209. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology DNA-damage Response EC 5.99.1.2 TOPO Topo I inhibitor lacking MDR1 and BCRP affinity Chemical name 2,3-Dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one Parent CAS No. [529488-28-6] Order Size Unit Price Stock 5 mg €95.00 In Stock
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Genz 644282

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2198

CAS [529488-28-6]

MF C22H21N3O5
MW 407.42

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

Genz 644282

Description

Topoisomerase I inhibitor (IC50 value 0.4 nM in human bone marrow CFU-GM assay). Cytotoxic agent, with activity toward 8 human tumor cell lines of varied histology and resistance mechanisms by colony formation, with enhanced potency compared to topotecan and SN-38. Contrary to the camptothecins, Genz-644282 is not a substrate for the multidrug resistance gene 1 (MDR1) and breast cancer resistance protein (BCRP) efflux pumps.
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