| 产品名称 | VX 680 - MK 0457 | Tozasertib |
| 产品货号 | Axon 1540 CAS [639089-54-6] MF C23H28N8OSMW 464.59 Purity: 98% Soluble in DMSO Description Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases References Certificates Categories Extra info EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 10, 262 - 267 (2004) GM Cheetham et al. Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett. 2007, 251, 323-329. FJ Giles et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007, 109, 500-502. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora inhibitor (non-specific) Chemical name Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide Parent CAS No. [639089-54-6] Order Size Unit Price Stock 10 mg €60.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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VX 680 - MK 0457 | TozasertibAxon 1540 CAS [639089-54-6] MF C23H28N8OS
Description
Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases
Aurora inhibitor (non-specific)
Chemical nameCyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide Parent CAS No.[639089-54-6] |
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