| 产品名称 | PF 05105679 |
| 产品货号 | Axon 2483 CAS [1398583-31-7] MF C26H21FN2O3MW 428.45 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description TRPM8 inhibitor (IC50 value 0.1 μM for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans. KEYWORDS: PF 05105679 | supplier | TRPM8 antagonist | PF05105679 | PF5105679 | CAS [1398583-31-7] | TRPM8 | Blocker | Ion Channels | transient receptor potential | TRP | cold | pain | analgesic | thermoregulation | melastatin | hypothermia |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PF 05105679Axon 2483 CAS [1398583-31-7] MF C26H21FN2O3
DescriptionTRPM8 inhibitor (IC50 value 0.1 μM for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans. KEYWORDS: PF 05105679 | supplier | TRPM8 antagonist | PF05105679 | PF5105679 | CAS [1398583-31-7] | TRPM8 | Blocker | Ion Channels | transient receptor potential | TRP | cold | pain | analgesic | thermoregulation | melastatin | hypothermia
TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans
Chemical name(R)-3-((N-(1-(4-fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid Parent CAS No.[1398583-31-7] |
| 产品资料 |
