产品名称

FG-4592 - Roxadustat | ASP 1517

产品货号

Axon 2588 CAS [808118-40-3] MF C19H16N2O5MW 352.34 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description New-generation oral HIF-PHD inhibitor (IC50 value 591 nM for inhibition of PHD2 in a fluorescence polarization assay) for the treatment of anemia in patients with chronic kidney disease (CKD) by promoting erythropoiesis. FG 4592 (Roxadustat) treatment significantly inhibited tert-Butyl hydroperoxide (TBHP)-induced apoptosis and increases the survival of neuronal PC-12 cells by stabilization of HIF-1α. FG 4592 is also shown to inhibit Fat Mass and Obesity Associated Protein (FTO; IC50 value 9.8 μM). KEYWORDS: FG-4592 | supplier | HIFα-PHD inhibitor | Roxadustat | ASP 1517 | FG4592 | ASP1517 | CAS [808118-40-3] | Hypoxia-signaling cascade | PHD-2 (HIF1) | Inhibitor | PHD2 | anemia | chronic kidney disease | CKD | erythropoiesis | survival | HIF-1α | Fat | Obesity Associated Protein | FTO

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

FG-4592 - Roxadustat | ASP 1517

Based on 259 reference(s) in Google Scholar 9 10 259

Axon 2588

CAS [808118-40-3]

MF C19H16N2O5
MW 352.34

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

FG-4592

Description

New-generation oral HIF-PHD inhibitor (IC50 value 591 nM for inhibition of PHD2 in a fluorescence polarization assay) for the treatment of anemia in patients with chronic kidney disease (CKD) by promoting erythropoiesis. FG 4592 (Roxadustat) treatment significantly inhibited tert-Butyl hydroperoxide (TBHP)-induced apoptosis and increases the survival of neuronal PC-12 cells by stabilization of HIF-1α. FG 4592 is also shown to inhibit Fat Mass and Obesity Associated Protein (FTO; IC50 value 9.8 μM).

KEYWORDS: FG-4592 | supplier | HIFα-PHD inhibitor | Roxadustat | ASP 1517 | FG4592 | ASP1517 | CAS [808118-40-3] | Hypoxia-signaling cascade | PHD-2 (HIF1) | Inhibitor | PHD2 | anemia | chronic kidney disease | CKD | erythropoiesis | survival | HIF-1α | Fat | Obesity Associated Protein | FTO

Y Lei et al. Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors. ACS Med Chem Lett. 2015 Nov 9;6(12):1236-40.

W Aik et al. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem. 2013 May 9;56(9):3680-8.

K Wu et al. Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016 Feb 1;1632:19-26.

Angiogenesis Apoptosis Cardiovascular Cell Signaling & Oncology CNS Diabetes & Metabolism PHD (HIF) Transcription Factors EC 1.14.11.29

New-generation oral HIF-PHD inhibitor

Chemical name

#NUM!

Parent CAS No.

[808118-40-3]

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