| 产品名称 | KRIBB11 |
| 产品货号 | Axon 2538 CAS [342639-96-7] MF C13H12N6O2MW 284.27 Purity: 99% Soluble in DMSO Description HSF1 inhibitor (IC50 value 1.2 µM for inhibition of heat shock-induced luciferase activity). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70, and induces growth arrest and apoptosis in HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of positive transcription elongation factor b (p-TEFb) to the hsp70 promoter, and tumor growth is inhibited without body weight loss upon intraperitoneal treatment of nude mice with KRIBB11. KRIBB11 enhances the cytotoxicity of nocodazole and parbendazole. KEYWORDS: KRIBB11 | supplier | HSF1 inhibitor | CAS [342639-96-7] | KRIBB 11 | DNA-RNA | HSF1 | Inhibitor | Transcription Factor | heat sock factor |HSP27 | HSF70 | apoptosis | growth arrest | p-TEFb |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
KRIBB11Axon 2538 CAS [342639-96-7] MF C13H12N6O2
DescriptionHSF1 inhibitor (IC50 value 1.2 µM for inhibition of heat shock-induced luciferase activity). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70, and induces growth arrest and apoptosis in HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of positive transcription elongation factor b (p-TEFb) to the hsp70 promoter, and tumor growth is inhibited without body weight loss upon intraperitoneal treatment of nude mice with KRIBB11. KRIBB11 enhances the cytotoxicity of nocodazole and parbendazole. KEYWORDS: KRIBB11 | supplier | HSF1 inhibitor | CAS [342639-96-7] | KRIBB 11 | DNA-RNA | HSF1 | Inhibitor | Transcription Factor | heat sock factor |HSP27 | HSF70 | apoptosis | growth arrest | p-TEFb
HSF1 inhibitor that blocks the induction of HSP27 and HSP70
Chemical nameN2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine Parent CAS No.[342639-96-7] |
| 产品资料 |
