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产品名称 FQI 1
产品货号 Axon 2157 CAS [599151-35-6] MF C18H17NO4MW 311.33 Purity: 99% Soluble in DMSO Description Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible. FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model. References Certificates Categories Extra info T.J. Granta et al. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. PNAS 2012, 109, 4503–4508.    H.C. Kang et al. Erythroid Cell-Specific α-Globin Gene Regulation by the CP2 Transcription Factor Family. Mol. Cell. Biol. 2005, 25, 6005–6020.  Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology CNS Immunology Pain & Inflammation CP2 Transcription Factors TF class 4 Inhibitor of α-globin transcription factor CP2 (LSF) Chemical name 8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one Parent CAS No. [599151-35-6] Order Size Unit Price Stock 10 mg €95.00 In Stock
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FQI 1

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2157

CAS [599151-35-6]

MF C18H17NO4
MW 311.33

  • Purity: 99%
  • Soluble in DMSO

FQI 1

Description

Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible. FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model.
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