产品名称

DMOG

产品货号

Axon 1977 CAS [89464-63-1] MF C6H9NO5MW 175.14 Purity: 99% Soluble in water and DMSO Description Cell-permeable HIF prolyl hydroxylase (PHD) inhibitor that enhances HIF-1α and -2α, vascular endothelial growth factor (VEGF), and platelet-endothelial cell adhesion molecule 1 expression in vitro. Moreover, DMOG combined with butyrate synergistically improved osteoblast differentiation and pro-angiogenic responses. DMOG is also known to delay neuronal cell death caused by trophic factor deprivation, and to ameliorate vasorelaxation after cold ischemia and hypochlorite-induced warm reperfusion injury. References Certificates Categories Extra info K.M. Woo et al. Synergistic effects of dimethyloxalylglycine and butyrate incorporated into α-calcium sulfate on bone regeneration. Biomaterials. 2015 Jan;39:1-14. D.J. Lomb et al. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem. 2007 Dec;103(5):1897-906. E. Baader et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 ( Pt 2):525-30. T.M. Asikainen et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10212-7. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Signaling & Oncology Epigenetics PHD (HIF) Transcription Factors EC 1.14.11.29 Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties Chemical name methyl 2-(2-methoxy-2-oxoethylamino)-2-oxoacetate Parent CAS No. [89464-63-1] Order Size Unit Price Stock 10 mg €65.00 In Stock

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axonmedchem

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DMOG

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1977

CAS [89464-63-1]

MF C6H9NO5
MW 175.14

Purity: 99%
Soluble in water and DMSO

DMOG

Description

Cell-permeable HIF prolyl hydroxylase (PHD) inhibitor that enhances HIF-1α and -2α, vascular endothelial growth factor (VEGF), and platelet-endothelial cell adhesion molecule 1 expression in vitro. Moreover, DMOG combined with butyrate synergistically improved osteoblast differentiation and pro-angiogenic responses. DMOG is also known to delay neuronal cell death caused by trophic factor deprivation, and to ameliorate vasorelaxation after cold ischemia and hypochlorite-induced warm reperfusion injury.