产品名称

RQ 00203078

产品货号

Axon 2498 CAS [1254205-52-1] MF C21H13ClF6N2O5SMW 554.85 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration. References Certificates Categories Extra info M. Ohmi et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8. Certificate of Analysis Material Safety Data Sheet CNS Miscellaneous Pain & Inflammation Unclassified TRPM8 Selective, potent, and orally active TRPM8 antagonist with in vivo activity Chemical name 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid Parent CAS No. [1254205-52-1] Order Size Unit Price Stock 10 mg €125.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

RQ 00203078

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2498

CAS [1254205-52-1]

MF C21H13ClF6N2O5S
MW 554.85

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

RQ 00203078

Description

Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration.

M. Ohmi et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8.

Selective, potent, and orally active TRPM8 antagonist with in vivo activity

Chemical name

4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

Parent CAS No.

[1254205-52-1]

产品资料