| 产品名称 | M8-B hydrochloride |
| 产品货号 | Axon 2423 CAS [883976-12-3] MF C22H24N2O3S.HClMW 432.96 Purity: 99% Soluble in water and DMSO Description Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel with in vitro and in vivo activity. M8-B blocked cold-induced and TRPM8-agonist-induced activation of TRPM8 channels (IC50 values 7.8 nM, 26.9 nM, and 64.3 nM following activation by cold, icilin or menthol, respectively), and decreased deep body temperature in mice and rats in vivo. M8-B did not block other TRP channels (IC50 > 20 μM). References Certificates Categories Extra info M.C. Almeida et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99. Certificate of Analysis Material Safety Data Sheet CNS Miscellaneous Pain & Inflammation Unclassified TRPM8 Selective and potent antagonist of the TRPM8 channel Chemical name N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride Parent CAS No. [884049-35-8] Order Size Unit Price Stock 10 mg €115.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
M8-B hydrochlorideAxon 2423 CAS [883976-12-3] MF C22H24N2O3S.HCl
Description
Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel with in vitro and in vivo activity. M8-B blocked cold-induced and TRPM8-agonist-induced activation of TRPM8 channels (IC50 values 7.8 nM, 26.9 nM, and 64.3 nM following activation by cold, icilin or menthol, respectively), and decreased deep body temperature in mice and rats in vivo. M8-B did not block other TRP channels (IC50 > 20 μM).
Selective and potent antagonist of the TRPM8 channel
Chemical nameN-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride Parent CAS No.[884049-35-8] |
| 产品资料 |
