产品名称

Clemizole

产品货号

Axon 2458 CAS [442-52-4] MF C19H20ClN3MW 325.84 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of the transient receptor potential channel TRPC5 with selectivity over other TRCP channels (IC50 values 9.1 µM, 6.4 µM, 1-1.3 µM, 11.3 µM, and 26.5 µM for TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7). Only weakly affected TRPM3 and TRPM8, and TRPV1-4 at markedly higher concentrations of Clemizole. Clemizole was originally developed as antihistaminergic drug and found to inhibit monoamine reuptake in the brain. Clemizole was also found to exhibit antiviral activity by inhibition of NS4B binding to RNA in HCV. References Certificates Categories Extra info J.M. Richter et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. T. Nguyen et al. Discovery of a novel member of the histamine receptor family. Mol Pharmacol. 2001 Mar;59(3):427-33. S. Einav et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. Certificate of Analysis Material Safety Data Sheet CNS Immunology Pain & Inflammation H1 Unclassified TRPC5 Inhibitor of the transient receptor potential channel TRPC5 Chemical name 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole Parent CAS No. [442-52-4] Order Size Unit Price Stock 10 mg €75.00 In Stock

产品价格

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

Clemizole

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2458

CAS [442-52-4]

MF C19H20ClN3
MW 325.84

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Clemizole

Description

Inhibitor of the transient receptor potential channel TRPC5 with selectivity over other TRCP channels (IC50 values 9.1 µM, 6.4 µM, 1-1.3 µM, 11.3 µM, and 26.5 µM for TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7). Only weakly affected TRPM3 and TRPM8, and TRPV1-4 at markedly higher concentrations of Clemizole. Clemizole was originally developed as antihistaminergic drug and found to inhibit monoamine reuptake in the brain. Clemizole was also found to exhibit antiviral activity by inhibition of NS4B binding to RNA in HCV.