产品名称

GW 441756

产品货号

Axon 1251 CAS [504433-23-2] MF C17H13N3OMW 275.30 Purity: 99% Moderately soluble in DMSO Description Potent and orally active TrkA kinase inhibitor (IC50= 2nM) References Certificates Categories Extra info ER Wood et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 2004, 14(4), 953-957. J Wang et al. Cellular Assays for High-Throughput Screening for Modulators of Trk Receptor Tyrosine Kinases. Curr. Chem. Genomics, 2008, 1, 27-33. EJ Jung et al. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp. Mol. Med. 2008, 40(3), 276–285. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology RTK class VII; EC 2.7.10.1 Trk TrkA inhibitor Chemical name 3-[1-(1-Methyl-1H-indol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one Parent CAS No. [504433-23-2] Order Size Unit Price Stock 5 mg €75.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GW 441756

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1251

CAS [504433-23-2]

MF C17H13N3O
MW 275.30

Purity: 99%
Moderately soluble in DMSO

GW 441756

Description

Potent and orally active TrkA kinase inhibitor (IC50= 2nM)

ER Wood et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 2004, 14(4), 953-957.

J Wang et al. Cellular Assays for High-Throughput Screening for Modulators of Trk Receptor Tyrosine Kinases. Curr. Chem. Genomics, 2008, 1, 27-33.

EJ Jung et al. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp. Mol. Med. 2008, 40(3), 276–285.

TrkA inhibitor

Chemical name

3-[1-(1-Methyl-1H-indol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one

Parent CAS No.

[504433-23-2]

产品资料