| 产品名称 | ANA 12 |
| 产品货号 | Axon 2468 CAS [219766-25-3] MF C22H21N3O3SMW 407.49 Purity: 100% Soluble in DMSO Description Selective TrkB antagonist (IC50 value 45.6 ± 8.4 nM for the high-affinity TetOn-rhTrkB) with anxiolytic and antidepressant activity in mice that inhibits processes downstream of TrkB without altering TrkA and TrkC functions. A valuable tool for studying BDNF/TrkB signaling. ANA-12 is also capable of reversing the diminished self-administration of cocaine in male CocSired rats by means of enhanced BDNF expression. References Certificates Categories Extra info M. Cazorla et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57. F.M. Vassoler et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Epigenetics RTK class VII; EC 2.7.10.1 Trk Selective TrkB antagonist with anxiolytic and antidepressant activity in mice Chemical name N-(2-(2-oxoazepan-3-ylcarbamoyl)phenyl)benzo[b]thiophene-2-carboxamide Parent CAS No. [219766-25-3] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
ANA 12Axon 2468 CAS [219766-25-3] MF C22H21N3O3S
Description
Selective TrkB antagonist (IC50 value 45.6 ± 8.4 nM for the high-affinity TetOn-rhTrkB) with anxiolytic and antidepressant activity in mice that inhibits processes downstream of TrkB without altering TrkA and TrkC functions. A valuable tool for studying BDNF/TrkB signaling. ANA-12 is also capable of reversing the diminished self-administration of cocaine in male CocSired rats by means of enhanced BDNF expression.
Selective TrkB antagonist with anxiolytic and antidepressant activity in mice
Chemical nameN-(2-(2-oxoazepan-3-ylcarbamoyl)phenyl)benzo[b]thiophene-2-carboxamide Parent CAS No.[219766-25-3] |
| 产品资料 |
