| 产品名称 | AZ 3146 |
| 产品货号 | Axon 1642 CAS [1124329-14-1] MF C24H32N6O3MW 452.55 Purity: 99% Soluble in DMSO Description Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor, with IC50 to be 35 nM for human Mps1 and selectivity against 46 out of a panel of 50 other kinases and only four kinases were inhibited by >40%, namely FAK, JNK1, JNK2, and KIT. AZ3146 overrides the spindle checkpoint References Certificates Categories Extra info L Hewitt et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex. J. Cell Biol. 2010, 190(1), 25-34. W Lan and DW Cleveland. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. 2010, 190 (1): 21-24. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Stem Cell MPS1 Kinase EC 2.7.12.1 MPS1 kinase inhibitor Chemical name 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one Parent CAS No. [1124329-14-1] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
AZ 3146Axon 1642 CAS [1124329-14-1] MF C24H32N6O3
Description
Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor, with IC50 to be 35 nM for human Mps1 and selectivity against 46 out of a panel of 50 other kinases and only four kinases were inhibited by >40%, namely FAK, JNK1, JNK2, and KIT. AZ3146 overrides the spindle checkpoint
MPS1 kinase inhibitor
Chemical name9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one Parent CAS No.[1124329-14-1] |
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