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产品名称 BFF 122 - BF 5
产品货号 Axon 2237 CAS [1152314-49-2] MF C17H19FN4O4MW 362.36 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Potent and selective inhibitor of kynurenine aminotransferase II (IC50 values ca. 1 μM and >30 μM for KAT II and KAT I respectively). Intrastriatal BFF 122 decreased newly formed KYNA by 66%, without influencing 3-HK or QUIN production in naïve rats. References Certificates Categories Extra info L. Amori et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J. Neurochem. 2009, 109, 316-325.   F. Rossi et al. Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J. Med. Chem. 2010, 53, 5684-5689. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS KAT II EC 2.6.1.7 Potent and selective inhibitor of kynurenine aminotransferase II Chemical name (S)-10-(4-aminopiperazin-1-yl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Parent CAS No. [1152314-49-2] Order Size Unit Price Stock 5 mg €165.00 In Stock
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BFF 122 - BF 5

Based on 24 reference(s) in Google Scholar 9 10 24

Axon 2237

CAS [1152314-49-2]

MF C17H19FN4O4
MW 362.36

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

BFF 122

Description

Potent and selective inhibitor of kynurenine aminotransferase II (IC50 values ca. 1 μM and >30 μM for KAT II and KAT I respectively). Intrastriatal BFF 122 decreased newly formed KYNA by 66%, without influencing 3-HK or QUIN production in naïve rats.
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