产品名称

OG-L002 hydrochloride

产品货号

Axon 2077 CAS [1357298-75-9] MF C15H15NO.HClMW 261.75 Purity: 100% Soluble in water and DMSO Description Highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 µM). OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles. References Certificates Categories Extra info Y Liang et al. A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency. MBio. 2013, 4, e00558-12. Inhibiting key protein halts herpes lytic cycle. mBioSphere on Feb 6, 2013. Z Watson et al. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology EC 1.14.11 Histone demethylase Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A) Chemical name 4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride Parent CAS No. [1357300-15-2] Order Size Unit Price Stock 5 mg €125.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

OG-L002 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2077

CAS [1357298-75-9]

MF C15H15NO.HCl
MW 261.75

Purity: 100%
Soluble in water and DMSO

OG-L002 hydrochloride

Description

Highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 µM). OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles.