产品名称

CGI 1746

产品货号

Axon 2018 CAS [910232-84-7] MF C34H37N5O4MW 579.69 Purity: 99% Soluble in DMSO Description Potent and highly selective inhibitor of Bruton's tyrosine kinase (Btk) (IC50: 1.9 nM); CGI1746 inhibits B cell signaling and functional effects References Certificates Categories Extra info JA Di Paolo et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat. Chem. Biol. 2011, 7(1), 41-50. Y Lou et al. Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies. J. Med. Chem. 2012, 55(10), 4539-4350. SL Tamn et al. Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders: Recent progress and therapeutic perspectives. Pharmacol. & Ther. 2013, 138(2), 294-309. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology BTK EC 2.7.10.2 Inhibitor of Bruton's tyrosine kinase (BTK) Chemical name 4-tert-butyl-N-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide Parent CAS No. [910232-84-7] Order Size Unit Price Stock 2 mg €85.00 In Stock

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现货询价，电话：010-67529703

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产品品牌

axonmedchem

产品概述

产品详情

CGI 1746

Based on 145 reference(s) in Google Scholar 9 10 145

Axon 2018

CAS [910232-84-7]

MF C34H37N5O4
MW 579.69

Purity: 99%
Soluble in DMSO

CGI 1746

Description

Potent and highly selective inhibitor of Bruton's tyrosine kinase (Btk) (IC50: 1.9 nM); CGI1746 inhibits B cell signaling and functional effects

JA Di Paolo et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat. Chem. Biol. 2011, 7(1), 41-50.

Y Lou et al. Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies. J. Med. Chem. 2012, 55(10), 4539-4350.

SL Tamn et al. Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders: Recent progress and therapeutic perspectives. Pharmacol. & Ther. 2013, 138(2), 294-309.

Inhibitor of Bruton's tyrosine kinase (BTK)

Chemical name

4-tert-butyl-N-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide

Parent CAS No.

[910232-84-7]

产品资料